A novel simultaneous clot‐fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders
نویسندگان
چکیده
منابع مشابه
Kinetics of fibrin clot lysis.
The principles relating the lysis times of fibrin clots to their contents of fibrin, plasminogen and plasminogen-activator were investigated. Mathematical considerations suggested that the square of the lysis time should correlate linearly with the fibrin content, and inversely with the activator and the plasminogen contents of the system. Experimental studies, during which these parameters wer...
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BACKGROUND Determination of clot lysis times on whole blood, diluted whole blood, plasma or plasma fraction has been used for many years to assess the overall activity of the fibrinolytic system. We designed a completely computerised semi-automatic 8-channel device for measurement and determination of fibrin clot lysis. The lysis time is evaluated by a mathematical analysis of the lysis curve a...
متن کاملA Method for Assessing Clot Lysis.
Clot lysis methods are used extensively in fibrinolytic work both for research into the physiology of the fibrinolytic system and for assay and standardization of enzymes. The following is a description of a simple method for measuring partial clot lysis using cheap and easily available apparatus and reagents. The method was first described by Blix in 1962 and has been adapted to suit the appar...
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Alzheimer disease is characterized by the presence of increased levels of the β-amyloid peptide (Aβ) in the brain parenchyma and cerebral blood vessels. This accumulated Aβ can bind to fibrin(ogen) and render fibrin clots more resistant to degradation. Here, we demonstrate that Aβ(42) specifically binds to fibrin and induces a tighter fibrin network characterized by thinner fibers and increased...
متن کاملEffects of actin filaments on fibrin clot structure and lysis.
The muscle and cytoskeletal protein actin is released from cells as a consequence of cell death and interacts with components of the hemostatic and fibrinolytic systems, including platelets, plasmin, and fibrin. We report here that incorporation of actin filaments into fibrin clots changes their viscoelastic properties by increasing their shear modulus at low deforming stresses and by nearly el...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2019
ISSN: 0007-1048,1365-2141
DOI: 10.1111/bjh.16111